Back to all Podcasts Can Stress Cause Depression? The Link Between Stress, Glutamate, and Synaptogenesis Craig Chepke, MD, DFAPA AUGUST 13, 2025 HMP · Can Stress Cause Depression? The Link Between Stress, Glutamate, and Synaptogenesis Craig Chepke, MD, DFAPA discusses how chronic stress alters glutamatergic signaling and contributes to MDD.